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Research projects

Research projects

In 2015 the following research projects are planned to be fulfilled:
  • The impact of the results of left-ventricular assist device implantation on
  • the quality and duration of life in patients with chronic heart failure. The solutions to the problems of diagnosis, treatment and management of patients with chronic heart failure in the Republic of Kazakhstan;
  • Genome-associated personalized anti-thrombotic therapy for patients with implanted left ventricular assist devices with high risk of thrombosis and bleeding, in collaboration with Center for Life Sciences, Nazarbayev University;
  • Development and clinical assessment of Haloplex cardiogenetic panel for detecting genetic predisposition and diagnosis of cardiac arrhythmias, in collaboration with Center for Life Sciences, Nazarbayev University.

Past projects:
  • Indicators of immune inflammatory processes and genetic markers of sudden cardiac death in patients with ventricular arrhythmia and atrial fibrillation. Principal investigator - M.S. Bekbossynova, 2011-2014.
  • The potassium and sodium channel genes KCNQ1, KCNE1/2, KCNH2 (HERG) and SCN5A mutations in patients with atrial fibrillation were studied in collaboration with Center for Life Sciences, Nazarbayev University. In total, a disease-causing mutation was identified in 59 of the 104 (56.5%) cases.
  • Ventricular tachycardia patients for genetic variants in the human Ryanodine Receptor 2Gene, hRYR2) was screened in a pilot study with Medical University Graz, Austria. Two novel mutations revealed. The results of the study published in PLoS One. 2014. 30, 9. (http://www.ncbi.nlm.nih.gov/pubmed/24978818).
  • Mutations on 96-CardioGene Panel in a ventricular tachycardia study cohort sequenced in collaboration with Medical University Graz, Austria. The 96-CardioGene Panel for candidate genes of the cardiac arrhythmias designed by the Medical University Graz in the frames of the project. A total of 1,422 variants were observed for the 95 cases. 87 of the mutations correspond to HGMD-listed disease-associated variants. A manuscript summarizing the results is in preparation.
  • Comparative study of immune status of study groups using low cytomerty and cytokine expression profiling.
  • 6 articles published, where two published in the international journals, and 15 abstracts and presentations submitted, 7 at international conferences.
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 HEART CENTER FUND

Our Fund was established by the initiative of the National Research Cardiac Surgery Center, and became the first foundation in Kazakhstan which focuses its efforts on promoting the development of cardiac surgery in Kazakhstan.

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